Butyl-Lithium Chemistry in the Flowid SpinPro Reactors

Flowid has performed experiments to improve the efficiency and safety of highly hazardous lithium-halogen exchange reactions. These experiments show the advantages of using the SpinPro technology versus conventional batch technology for these kinds of reactions. Key results are the ease of scaling up to commercial production and flexibility to perform different chemical reactions in the [...]

SpinPro R300 eliminates necessity of Hydrogen Sulphide in Multiphase reaction

The SpinPro reactor has recently been used on-site. Goal of this project was to experimentally determine the performance of the SpinPro reactor for a multiphase reaction between a gas and two liquid phases, one aqueous and one oil. The rate-limiting step in this process was believed to lie in the mass transfer steps; an ideal [...]

Whitepaper: Successful Scale Up of Butyl-Lithium using the SpinPro Reactor

In a pursuit of improving safety and process efficiency, Biogen a top Biotech company collaborated with Proteaf Technologies and Flowid to scale up a highly hazardous lithium-halogen exchange followed by quench reaction sequence at ChemConnection, Oss, NL. The sequence demonstrated successful scale up of laboratory spinning disk technology to the SpinPro-- a production scale spinning [...]

SpinPro Reactor for Butyl Lithium Reaction

Flowid demonstrated that the SpinPro Reactor is well suited for performing hazardous and pyrophoric Lithium Halogen Exchange. An extensive engineering and safety effort resulted in successful experiments. Lithium Halogen Exchange is a type of carbon-carbon bond forming reaction frequently performed in lab scale organic synthesis. Although the reaction is performed at scale, producing pharmaceuticals, pesticides, [...]