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Whitepaper: Successful Scale Up of Butyl-Lithium using the SpinPro Reactor

In a pursuit of improving safety and process efficiency, Biogen a top Biotech company collaborated with Proteaf Technologies and Flowid to scale up a highly hazardous lithium-halogen exchange followed by quench reaction sequence at ChemConnection, Oss, NL. The sequence demonstrated successful scale up of laboratory spinning disk technology to the SpinPro-- a production scale spinning [...]

AkzoNobel making a big effort on breakthrough technology

Published in 'Duurzaam Geproduceerd', courtesy of Wim Raaijen AkzoNobel Industrial Chemicals wants to apply more novel process technology. The company developed a methodology to hasten it. Innovation Director Marco Waas in the new edition of Dutch magazine : “Duurzaam Geproduceerd”: "We are currently investigating the possibility of making chlorine with the Spinning Disc on a small [...]

SpinPro Reactor for Butyl Lithium Reaction

Flowid demonstrated that the SpinPro Reactor is well suited for performing hazardous and pyrophoric Lithium Halogen Exchange. An extensive engineering and safety effort resulted in successful experiments. Lithium Halogen Exchange is a type of carbon-carbon bond forming reaction frequently performed in lab scale organic synthesis. Although the reaction is performed at scale, producing pharmaceuticals, pesticides, [...]

Phase Transfer Catalyzed Reaction in Micro Flow Chemistry

Summary This application Note describes the benefits of micro flow chemistry for biphasic liquid-liquid reactions with a Phase Transfer Catalyzed (PTC) type of reaction. For a model reaction Flowid realized a 3 times higher production rate per day with a higher selectivity (99%) as compared to batch reactions. Due to the continuous nature of the [...]

By |april 11th, 2011|case, chemistry, efficient, micro reactor, mixing, reaction|1 Comment