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Butyl-Lithium Chemistry in the Flowid SpinPro Reactors

Flowid has performed experiments to improve the efficiency and safety of highly hazardous lithium-halogen exchange reactions. These experiments show the advantages of using the SpinPro technology versus conventional batch technology for these kinds of reactions. Key results are the ease of scaling up to commercial production and flexibility to perform different chemical reactions in the [...]

Whitepaper: Successful Scale Up of Butyl-Lithium using the SpinPro Reactor

In a pursuit of improving safety and process efficiency, Biogen a top Biotech company collaborated with Proteaf Technologies and Flowid to scale up a highly hazardous lithium-halogen exchange followed by quench reaction sequence at ChemConnection, Oss, NL. The sequence demonstrated successful scale up of laboratory spinning disk technology to the SpinPro-- a production scale spinning [...]

SpinPro Reactor for Butyl Lithium Reaction

Flowid demonstrated that the SpinPro Reactor is well suited for performing hazardous and pyrophoric Lithium Halogen Exchange. An extensive engineering and safety effort resulted in successful experiments. Lithium Halogen Exchange is a type of carbon-carbon bond forming reaction frequently performed in lab scale organic synthesis. Although the reaction is performed at scale, producing pharmaceuticals, pesticides, [...]

Case study – Flexibility

Problem Description One of our customers, a large manufacturer of flow reactors in the (pharma) industry, was looking for a suitable testing site to further develop a highly exothermic process using dangerous chemicals. They had had success in small scale research and wanted to optimize and scale up the process. However, after having requested access [...]

By |maart 10th, 2014|case, flexible, flowflex, market, micro reactor, pharma, reaction|0 Comments

Phase Transfer Catalyzed Reaction in Micro Flow Chemistry

Summary This application Note describes the benefits of micro flow chemistry for biphasic liquid-liquid reactions with a Phase Transfer Catalyzed (PTC) type of reaction. For a model reaction Flowid realized a 3 times higher production rate per day with a higher selectivity (99%) as compared to batch reactions. Due to the continuous nature of the [...]

By |april 11th, 2011|case, chemistry, efficient, micro reactor, mixing, reaction|0 Comments