reaction

Butyl-Lithium Chemistry in the Flowid SpinPro Reactors

Flowid has performed experiments to improve the efficiency and safety of highly hazardous lithium-halogen exchange reactions. These experiments show the advantages of using the SpinPro technology versus conventional batch technology for these kinds of reactions. Key results are the ease of scaling up to commercial production and flexibility to perform different chemical reactions in the [...]

Precise and Accurate Emulsification in the SpinPro

The SpinPro is unique in the field of emulsification as it allows for a high degree of freedom on the amount of shear that is applied to the emulsifying fluids, independent of the total throughput through the system. This results in constant droplet size distribution at the outlet with a high degree of control. Recently, [...]

Chimex Dosing Skid

Chimex is a French company that designs, develops, and markets increasingly eco-friendly processes for the fine chemical, biotech, and cosmetic industries. Flowid has recently engineered and realised the construction of a dosing skid for Chimex. The skid complies with ATEX regulations and is constructed completely using highly chemically resistant materials. The configuration comprises two high-end [...]

By |februari 23rd, 2016|chemistry, dosing systems, micro reactor, ProcesEngineering, reaction|0 Comments

Whitepaper: Successful Scale Up of Butyl-Lithium using the SpinPro Reactor

In a pursuit of improving safety and process efficiency, Biogen a top Biotech company collaborated with Proteaf Technologies and Flowid to scale up a highly hazardous lithium-halogen exchange followed by quench reaction sequence at ChemConnection, Oss, NL. The sequence demonstrated successful scale up of laboratory spinning disk technology to the SpinPro-- a production scale spinning [...]

SpinPro Reactor for Butyl Lithium Reaction

Flowid demonstrated that the SpinPro Reactor is well suited for performing hazardous and pyrophoric Lithium Halogen Exchange. An extensive engineering and safety effort resulted in successful experiments. Lithium Halogen Exchange is a type of carbon-carbon bond forming reaction frequently performed in lab scale organic synthesis. Although the reaction is performed at scale, producing pharmaceuticals, pesticides, [...]

SpinPro Reactor suited for Butyl Lithium reaction

Flowid demonstrated that the SpinPro Reactor is well suited for performing hazardous and pyrophoric Lithium Halogen Exchange. An extensive engineering and safety effort resulted in successful experiments performed in Flowid’s own facilities in Eindhoven, The Netherlands. Lithium Halogen Exchange is a type of carbon-carbon bond forming reaction frequently performed in lab scale organic synthesis. Although [...]

Case study – Flexibility

Problem Description One of our customers, a large manufacturer of flow reactors in the (pharma) industry, was looking for a suitable testing site to further develop a highly exothermic process using dangerous chemicals. They had had success in small scale research and wanted to optimize and scale up the process. However, after having requested access [...]

By |maart 10th, 2014|case, flexible, flowflex, market, micro reactor, pharma, reaction|0 Comments

Quantum Dot Continuous Flow Processing Breakthrough Achieved

With this advance, researchers and manufacturers have the opportunity to now incorporate Quantum Materials Tetrapod Quantum Dots into new state-of-the-art electronics products that require industrial scale amounts of material. This new quantum dot production process using a new microreactor and software controlled continuous flow process has been successfully developed and operated for delivery of mass produced [...]

By |september 13th, 2011|chemistry, market, micro reactor, reaction|0 Comments

Phase Transfer Catalyzed Reaction in Micro Flow Chemistry

Summary This application Note describes the benefits of micro flow chemistry for biphasic liquid-liquid reactions with a Phase Transfer Catalyzed (PTC) type of reaction. For a model reaction Flowid realized a 3 times higher production rate per day with a higher selectivity (99%) as compared to batch reactions. Due to the continuous nature of the [...]

By |april 11th, 2011|case, chemistry, efficient, micro reactor, mixing, reaction|0 Comments