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Butyl-Lithium Chemistry in the Flowid SpinPro Reactors

Flowid has performed experiments to improve the efficiency and safety of highly hazardous lithium-halogen exchange reactions. These experiments show the advantages of using the SpinPro technology versus conventional batch technology for these kinds of reactions. Key results are the ease of scaling up to commercial production and flexibility to perform different chemical reactions in the [...]

Precise and Accurate Emulsification in the SpinPro

The SpinPro is unique in the field of emulsification as it allows for a high degree of freedom on the amount of shear that is applied to the emulsifying fluids, independent of the total throughput through the system. This results in constant droplet size distribution at the outlet with a high degree of control. Recently, [...]

Making the impossible possible: Butyl Lithium chemistry

The companies ChemConnection B.V., Ajinomoto Omnichem N.V. and Flowid B.V., in cooperation with ISPT, started a combined project, partially funded by the Netherlands Enterprise Agency (RVO), to investigate the potential of performing organic synthesis with butyl lithium as reagent in a SpinPro Reactor. Motivation of the project was to proof the outstanding performance of the [...]

By |april 1st, 2016|chemistry, pharma, spinpro reactor, SpinProReactor|0 Comments

Whitepaper: Successful Scale Up of Butyl-Lithium using the SpinPro Reactor

In a pursuit of improving safety and process efficiency, Biogen a top Biotech company collaborated with Proteaf Technologies and Flowid to scale up a highly hazardous lithium-halogen exchange followed by quench reaction sequence at ChemConnection, Oss, NL. The sequence demonstrated successful scale up of laboratory spinning disk technology to the SpinPro-- a production scale spinning [...]

SpinPro Reactor for Butyl Lithium Reaction

Flowid demonstrated that the SpinPro Reactor is well suited for performing hazardous and pyrophoric Lithium Halogen Exchange. An extensive engineering and safety effort resulted in successful experiments. Lithium Halogen Exchange is a type of carbon-carbon bond forming reaction frequently performed in lab scale organic synthesis. Although the reaction is performed at scale, producing pharmaceuticals, pesticides, [...]

SpinPro Reactor suited for Butyl Lithium reaction

Flowid demonstrated that the SpinPro Reactor is well suited for performing hazardous and pyrophoric Lithium Halogen Exchange. An extensive engineering and safety effort resulted in successful experiments performed in Flowid’s own facilities in Eindhoven, The Netherlands. Lithium Halogen Exchange is a type of carbon-carbon bond forming reaction frequently performed in lab scale organic synthesis. Although [...]