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Butyl-Lithium Chemistry in the Flowid SpinPro Reactors

Flowid has performed experiments to improve the efficiency and safety of highly hazardous lithium-halogen exchange reactions. These experiments show the advantages of using the SpinPro technology versus conventional batch technology for these kinds of reactions. Key results are the ease of scaling up to commercial production and flexibility to perform different chemical reactions in the [...]

Precise and Accurate Emulsification in the SpinPro

The SpinPro is unique in the field of emulsification as it allows for a high degree of freedom on the amount of shear that is applied to the emulsifying fluids, independent of the total throughput through the system. This results in constant droplet size distribution at the outlet with a high degree of control. Recently, [...]

Making the impossible possible: Butyl Lithium chemistry

The companies ChemConnection B.V., Ajinomoto Omnichem N.V. and Flowid B.V., in cooperation with ISPT, started a combined project, partially funded by the Netherlands Enterprise Agency (RVO), to investigate the potential of performing organic synthesis with butyl lithium as reagent in a SpinPro Reactor. Motivation of the project was to proof the outstanding performance of the [...]

By |april 1st, 2016|chemistry, pharma, spinpro reactor, SpinProReactor|0 Comments

The SpinPro R300; not your everyday Spinning Disc Reactor

The SpinPro reactor is based on patented rotor-stator spinning disc technology. Traditionally, two types of spinning disc reactors are known in chemical industry. The first, the thin film spinning disc reactor consists of a rotating disk in a large collection tank. Liquid is fed on top of the disc near the axis of rotation and flows [...]

By |februari 24th, 2016|Blog, NoNews, SpinProReactor|0 Comments

Chimex Dosing Skid

Chimex is a French company that designs, develops, and markets increasingly eco-friendly processes for the fine chemical, biotech, and cosmetic industries. Flowid has recently engineered and realised the construction of a dosing skid for Chimex. The skid complies with ATEX regulations and is constructed completely using highly chemically resistant materials. The configuration comprises two high-end [...]

By |februari 23rd, 2016|chemistry, dosing systems, micro reactor, ProcesEngineering, reaction|0 Comments

SpinPro R300 eliminates necessity of Hydrogen Sulphide in Multiphase reaction

The SpinPro reactor has recently been used on-site. Goal of this project was to experimentally determine the performance of the SpinPro reactor for a multiphase reaction between a gas and two liquid phases, one aqueous and one oil. The rate-limiting step in this process was believed to lie in the mass transfer steps; an ideal [...]

Whitepaper: Successful Scale Up of Butyl-Lithium using the SpinPro Reactor

In a pursuit of improving safety and process efficiency, Biogen a top Biotech company collaborated with Proteaf Technologies and Flowid to scale up a highly hazardous lithium-halogen exchange followed by quench reaction sequence at ChemConnection, Oss, NL. The sequence demonstrated successful scale up of laboratory spinning disk technology to the SpinPro-- a production scale spinning [...]

SpinPro Reactor for Butyl Lithium Reaction

Flowid demonstrated that the SpinPro Reactor is well suited for performing hazardous and pyrophoric Lithium Halogen Exchange. An extensive engineering and safety effort resulted in successful experiments. Lithium Halogen Exchange is a type of carbon-carbon bond forming reaction frequently performed in lab scale organic synthesis. Although the reaction is performed at scale, producing pharmaceuticals, pesticides, [...]

SpinPro Reactor suited for Butyl Lithium reaction

Flowid demonstrated that the SpinPro Reactor is well suited for performing hazardous and pyrophoric Lithium Halogen Exchange. An extensive engineering and safety effort resulted in successful experiments performed in Flowid’s own facilities in Eindhoven, The Netherlands. Lithium Halogen Exchange is a type of carbon-carbon bond forming reaction frequently performed in lab scale organic synthesis. Although [...]

Flowid Pilot Plant Capabilities

In eleven weeks Flowid engineered and constructed a pharmaceutical pilot plant. This plant is in operation since the beginning of 2014 in Flowid’s pilot hall. We look forward to discuss our pilot plant capabilities with you. A static mixer forms the hart of the pilot plant. Flowid is specialised in continues processing based on technologies [...]

By |juni 2nd, 2014|market, mixing, pharma, ProcesEngineering, StaticMixer|0 Comments