Bezoek aan MSD Oss, voorheen Organon.Foto: Mischa Keijser

Pharma

Continuous API Synthesis Process Engineering Expertise

We combine our customers’ indispensable process knowledge and our own expertise and technology to create safe, efficient and flexible solutions that line up perfectly with our customers’ needs. By developing continuous processes we reduce your manufacturing cost, increase your energy efficiency while improving yield and selectivity and achieve a safer and more flexible operation.

Increases in yield and selectivity are possible between 3% for dedicated, and 25% for multipurpose facilities depending on process characteristics and kinetics. This is possible due to steady state operation in continuous processes. A significant reduction in energy usage is gained by the extended operating window. This allows elevated pressures and temperatures. Due to the small internal volumes pressures up to 100 bar and temperatures up to 180°C are possible on standard equipment.
Small internal volumes make processes intrinsic safe. Small hold-ups enable the safe handeling of dangerous intermediates. Great proces controllability has more advantages than better yields. It allows you come to a safe stop at all time. Stopping the dosing system stops the process in seconds. The processes controllability allows you to adjust process parameters during operation based on measured output, keeping your product within specs.
Produce exactly the required amount of product required at a specific moment or location. Switch between different products or grades in minutes. Processes and equipment designed and built by Flowid is compact and contain low volumes. Full automation with pleasant graphical interfaces form our signature.

To achieve all this, we develop continuous process solutions and products that can be implemented in all stages of the product development process: from R&D to pilot plants. Our solutions are easily scalable from pilot to full scale production capacity. Our solutions have a great look & feel and have very user friendly interfaces, which put the user firmly in control of all their processes.

Examples relevant for the pharmaceutical industry:

Precise and Accurate Emulsification in the SpinPro

By |juli 27th, 2016|Categories: case, chemistry, pharma, ProcesEngineering, reaction, spinpro reactor, SpinProReactor, uncategorized|

The SpinPro is unique in the field of emulsification as it allows for a high degree of freedom on the amount of shear that is applied to the emulsifying fluids, independent of the total throughput [...]

Making the impossible possible: Butyl Lithium chemistry

By |april 1st, 2016|Categories: chemistry, pharma, spinpro reactor, SpinProReactor|

The companies ChemConnection B.V., Ajinomoto Omnichem N.V. and Flowid B.V., in cooperation with ISPT, started a combined project, partially funded by the Netherlands Enterprise Agency (RVO), to investigate the potential of performing organic synthesis with [...]

Whitepaper: Successful Scale Up of Butyl-Lithium using the SpinPro Reactor

By |juli 1st, 2015|Categories: Applications, BuLi, case, chemistry, efficient, pharma, reaction, safe, spinpro reactor|

In a pursuit of improving safety and process efficiency, Biogen a top Biotech company collaborated with Proteaf Technologies and Flowid to scale up a highly hazardous lithium-halogen exchange followed by quench reaction sequence at ChemConnection, [...]

SpinPro Reactor for Butyl Lithium Reaction

By |maart 6th, 2015|Categories: Applications, BuLi, efficient, pharma, ProcesEngineering, reaction, safe, spinpro reactor, SpinProReactor|

Flowid demonstrated that the SpinPro Reactor is well suited for performing hazardous and pyrophoric Lithium Halogen Exchange. An extensive engineering and safety effort resulted in successful experiments. Lithium Halogen Exchange is a type of carbon-carbon [...]

The SpinPro Extractor and Highly Asymmetric Flows

By |maart 4th, 2015|Categories: agro-food, chemistry, pharma, separation, spinpro extractor, SpinProReactor|

Flowid has recently proven the high extraction efficiency of its SpinPro Extractor using a standardised extraction system for benchmarking. The extraction involved the washing of a solution of acetone in toluene with water and yielded [...]

Heterogeneous Catalysis in the SpinPro Reactor

By |februari 17th, 2015|Categories: biobased, chemistry, mixing, pharma, reaction, spinpro reactor, SpinProReactor|

Heterogeneous catalysis is of paramount importance in chemical industry, but it often involves incorporating difficult and mass transfer limited unit operations. The SpinPro Reactor has proven itself to drastically increase solid-liquid mass transfer rates, while [...]