Next Generation Reactor Engineering
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Brightlands Chemelot Campus getting plant with revolutionary green chemical technology
2015.01.01 Press Release by Flowid and Brightlands Chemelot Campus

Flowid from Eindhoven is constructing a small-scale plant at Brightlands Chemelot Campus in Sittard-Geleen. This so-called “Spin-in” project will cost 1.7 million euros, over 700,000 of which is provided as funding from the South Netherlands Operational Program (OP South – “OP-Zuid” in Dutch). In the plant, the young company will be applying patented spinning-disk technology on an industrial scale. This concerns a new type of chemical reactor, which is not only much smaller than conventional reactors, but also much safer, more efficient and more environmentally-friendly. The plant should be finished in late 2015.

The technology, for which Flowid recently received the Herman Wijffels Innovation Award, has major potential, and may significantly boost employment and sales at the supplying industry. The market targeted by Flowid is worth hundreds of millions of euros.

For the development of the plant, Flowid is collaborating with Eindhoven University of Technology (TU/e), where the technology was developed, and with Brightlands Chemelot Campus, where the necessary facilities for these types of plants are present.

The project is supported by the European Regional Development Fund and the government with funding from OP-Zuid, as it is aimed at the further development and marketing of a new type of process technology.

Member of the Provincial Executive Twan Beurskens (Economic Affairs, Province of Limburg) is delighted by the arrival of Flowid: ‘This is a huge gain for Brightlands Chemelot Campus, and for the economy in Limburg. You can see new companies making more and more use of the knowledge present at knowledge institutes such as TU/e, and also managing to secure funds from European funding programs. The campuses in Limburg are the crystallization point of these innovative developments. Flowid is a fantastic addition to our knowledge economy!’

Spinning-disk technology
In a spinning-disk reactor, various liquids are fed from above onto horizontally positioned disks. The disks, about the size of a CD, rotate rapidly in a tight-fitting casing. The substances mix due to the centrifugal forces, while being pumped along the spinning disks. The substances enter a chemical reaction in well-controllable conditions and the product formed is collected.

Follow this link for an animated video of the technology:
http://www.flowid.nl/documents/ReactorMP4.mp4

Spinning-disk technology stands out from common technologies due to the smaller size of the reactors, a reduced use of energy and raw materials, less or no waste production and the lower operational and investment costs. The smaller dimensions and the intrinsic safety of the system make it suitable for small-scale production. This is a high-value feature, seeing that it is preferable to process bio-based raw materials locally, at the source (to prevent transport of water in the biomass).

Upscaling
At Brightlands Chemelot Campus, Flowid will be upscaling the spinning-disk technology from a laboratory to an industrial environment. This will allow the capacity to be raised from 8 m3 to 80 m3 per day, which is more than enough for many applications. The campus offers an environment in which the requirements, for example, relating to safety and infrastructure are met. Additionally, potential buyers are also present at the campus.

The spinning-disk reactor will be used, among other things, for the development and improvement of bio-based production processes. After all, a lot of research is still required into the most adequate conversion of plant-based material into useful building blocks for materials.

Relationship with other campus activities
Due to the usefulness of the reactor for bio-based production processes, Flowid dovetails with other activities at Brightlands Chemelot Campus, in particular the Chemelot InSciTe (Institute for Science and Technology) scientific center. This center, which is being established, will be focusing on the development, production, testing and perfecting of building blocks for bio-based materials.

In this regard, the plant fits in with the development of new pilot-plant facilities at the campus, which – among other things – are geared towards the production of building blocks for bio-based materials. Once these facilities are finished, Flowid will be able to use them.

Government support
The Flowid plant was made possible in part by support from the government from the South Netherlands Operational Program (OP-Zuid). This is a joint funding program by the provinces of Limburg, North Brabant and Zeeland, together with the cities of Breda, Tilburg, 's‑Hertogenbosch, Eindhoven, Helmond, Venlo, Sittard-Geleen, Heerlen and Maastricht for activities that are co-funded by the European Regional Development Fund (ERDF). The funding for this project allocated through OP-Zuid is funded by ERDF and the central government.

Flowid had previously received a Valorization Grant of 225,000 euros from Technologiestichting STW to introduce the spinning-disk technology on the market.

Eindhoven University of Technology
Eindhoven University of Technology (TU/e) is a research university that specializes in engineering, science and technology. The spinning-disk technology was developed by the Chemical Reactor Engineering research group, which was also the birthplace of Flowid. The aim of this research group is to understand and monitor the interaction between physical transport phenomena, catalytic activity and reaction and separation processes for various applications. For more information: www.tue.nl

Flowid
Flowid Products B.V. is a spin-off of Eindhoven University of Technology. The company develops, builds and tests radically innovative process technology solutions for the process industry and by now has built up seven years of experience in continuous process solutions. Flowid employs 12 staff members. For more information: www.flowid.nl

Brightlands Chemelot Campus
At Brightlands Chemelot Campus, research and development are performed and education is provided in the field of chemistry and materials, and related life sciences. The focus is on high-performance materials, biomedical materials and bio-based materials. The campus is developing into a creative breeding ground for innovation and new businesses, with thousands of highly-trained workers. This dynamic has been created in part through collaboration between the business community, educational and knowledge institutes, and the authorities. The campus provides an active contribution through activities such as facilitating the construction of pilot plants. Chemelot Campus collaborates with Maastricht Health Campus under the name Brightlands. Brightlands also relates to the research program of Maastricht University, Zuyd Hogeschool and the Province of Limburg. For more information: www.brightlands.com

OP-Zuid
The South Netherlands Operational Program (OP-Zuid) is a joint funding program by the provinces of Zeeland, North Brabant and Limburg, together with the cities of Breda, Tilburg, 's-Hertogenbosch, Eindhoven, Helmond, Venlo, Sittard-Geleen, Heerlen and Maastricht. It is an economic boost program that is partly funded by the European Regional Development Fund (ERDF) for almost €186 million and by the government for €46 million. The main objectives of OP-Zuid are promoting competitiveness, sustainable economic growth and improving employment in the south of the Netherlands. For more information:www.op-zuid.nl

Download the press release in English
Download the press release in Dutch

Flowid wins Herman Wijffels Innovation Award
2014.10.30 News update by Flowid

Flowid has been awarded the Herman Wijffels Innovation Award in the circulair economy category. The jury concluded that Flowid's factories of the future enable decentralised production, without big factories, without large investments. They conclude employment and knowledge is retained while maintaining a leading position in proces industry.

Flowid finalist Herman Wijffels Innovation Award
2014.10.06 News update by Flowid

Flowid is one of the nine finalists for the Herman Wijffels Innovation Award. Flowid is nominated in the Circular Economy category out of 600 nominees. Help Flowid the win this award by voting for 'The Factories of the Future' (De fabrieken van de toekomst)

HermanWijffels

Flowid Pilot Plant capabilities
2014.06.02 News update by Flowid

In eleven weeks Flowid engineered and constructed a pharmaceutical pilot plant. This plant is in operation since the beginning of 2014 in Flowid’s pilot hall. We look forward to discuss our pilot plant capabilities with you.

Flowid phama pilot plant

Launch of Flowid Production Units at Hannover Messe
2014.04.07 News update by Flowid

Flowid currently exhibits at the Hannover Messe in the Holland High Tech Pavillion. Hall 2 D10. Two transportable production units are presented. The Reactor en Extractor production units are based on the Spinid spinning disc technology. You can watch an interview with Flowid and see the units in operation here. We are looking forward to discuss this technology with you and jointly work on new applications.

Flowid SpinPro Spinning disc pilot plants

TEDxBinnenhof talk Jeoffrey van den Berg
HOW TO CONTROL EXPLOSIVE ENTHUSIASM

2014.03.31 TEDxBinnenhof



Being a modern high-tech entrepreneur, Jeoffrey has a vision of changing the chemical industry. In his view, big factories are a thing of the past; the future belongs to smaller plants. Materials, ingredients and additives should be made on the spot, where and as they are needed. He believes that, with his spinning disc technology, he has made a big step forward in realising this scenario. TEDxBinnenhof

NiTech Cooperation
2014.03.03 News update by Flowid

To offer a broader spectrum of continuous processing solutions to our customers Flowid signed an agreement with NiTech. Their oscillating baffled reactors offer great solutions for crystalisation processes and slower reactions.

Nitech

Flowid exhibits at Hannover Messe
2014.02.24 News update by Flowid

At the Hannover Messe, worlds largest technology exhibition Flowid exhibits from the 7th until the 11th of April. Flowid will be located in hall 2 at the Holland High Tech House.

Flowid speaks at TEDxBinnenhof
2014.01.17 Press release by Flowid

Global Challenges, Dutch Solutions is the headline for TEDxBinnenhof 2014. Flowid is one out of ten speakers selected by André Kuipers, TEDx licensee Jim Stolze, Bertholt Leeflink Director-General Entrepreneurship and Innovation at the Dutch Ministry of Economic Affairs. Ideas worth spreading is what TED is all about. TEDxBinnenhof does that in an unique way. Not only will the event be live-streamed during viewing parties at prominent locations, but also to more than 40 Dutch embassies and consulates all over the world. In that way the ideas of Flowid will reach a worldwide audience by talk of Jeoffrey van den Berg.

Flowid Jeoffrey van den Berg TEDxBinnenhof speaker

Proces Enlightenment 2013: Spinning Disc
Spinid awarded during ‘Duurzaam geproduceerd’ congres
2013.11.25 Press release by Flowid

During the Dutch congres 'Duurzaam Geproduceerd' about sustainable production, the Spinning Disc was award the Proces Enlightenment award 2013. The results were announced after deliberation by the jury, headed by Marga Angle , director of ‘De Groene Zaak’, an online election with nearly 15 thousand votes were cast , and a public vote during the Sustainable Production Congress. The jury put emphasis about the 'people side' : Spinning Disc also concerns about project worker safety , according to the jury.

DuurzaamGeproduceerd

IChemE 2013: Going for a Spin
Spinning disc gets most prestigious chemical engineering award in the world
2013.11.07 News update by Flowid

The rotor-rotor multiple spinning disc extractor has been awarded the Core Chemical Engineering Award 2013 by the Institution of Chemical Engineers. The IChemE 2013 Awards provide a platform to recognise and reward chemical engineering innovation and excellence. The awards were presented at a gala dinner at the Bolton Whites Hotel, Bolton (UK). John van der Schaaf of the Eindhoven University of Technology was there to collect the award.

The Core Chemical Engineering Award is sponsored by Simon Carves Engineering and recognises the project or process that best demonstrates a chemical engineering solution to improve resource efficiency, lifetime value and/or process optimisation. The award was presented to the Eindhoven University of Technology team for the work done in the last years on the development and implementation of spinning disc technology.

IchemE

The winning contribution was shortlisted among five other contributions from Harvard University, AstraZeneca, Atkins, Britest (The F3 Factory) and BP.

Proteaf and Flowid start cooperating
2013.07.02 News update by Flowid

A two sided agent agreement has been signed by Proteaf Technologies LCC and Flowid BV. Proteaf represents Flowid for the North American territory and vice versa.

Proteaf offers scalable application specific solutions based on off-the-shelf instrumentation supported by custom engineering and chemistry research and development services.

FlowFlex platform launched
2013.05.31 News update by Flowid

The FlowFlex is an automated modular continuous process development platform. The set-up is highly flexible in performing different kinds of flow chemistry based on different continuous technologies. All modules have the same dimensions and can be interconnected easily due to its uniform power, data and process interconnections.

Flowid Plug&Produce skid

For more information go to the FlowFlex product page.

SPIE Controlec Engineering BV and Flowid BV Sign Declaration of Intent
2012.09.21 Press release by Flowid

On Holland's largest three-masted schooner ‘De Eendracht’, SPIE Controlec Engineering and Flowid signed a declaration of intent to form a strategic alliance for the joint execution of projects.

The alliance foresees clear synergy effects for clients of both organizations when specific know-how and expertise is bundled. Initial focus will be on implementing spinning disc reactors. According to Auke de Leeuw, director of SPIE Controlec Engineering; it is a technology with huge potential and different applications in abundance. “This could be ‘the new revolution’ within the process industry”.

Eendracht SPIE Flowid cooperation

Flowid Extents Facilities
2012.08.17 Press release by Flowid

Flowid further extended their facilities on the campus of the Eindhoven University of Technology. The ‘Helix building’ could no longer meet Flowid’s demands. More office space and pilot hall facilities are required to support Flowid’s activities. Together with the Department of Chemical Reactor Engineering Flowid decided that keeping activities of both in close proximity of each other was favored over extending towards the new 'Catalyst' incubator building on the University campus.

The new offices are realized in the neighboring 'Matrix' building. These offices are renovated and equipped according to Flowid standards. All offices have a beautiful lookout over the pilot hall facilities. In July 2012 the movement started and in August 2012 it was completed.

While the telephone number and email addresses of Flowid are maintained, the visiting address has been changed to:

Flowid BV
Den Dolech 2, Matrix 1.36-40

You are more than welcome to visit us in our new facilities!

Flowid and EmulTech realize unique platform for emulsification processes
2012.07.04 Press release by Flowid

The Eindhoven high-tech companies Flowid B.V. and EmulTech B.V. cooperated in the realization of a unique laboratorial platform for EmulTech’s ET4ME technology. This patented microfluidic technology is used for the development of drug delivery formulations with high degree of uniformity, solubility, tailored release, benign processes and reproducibility. Flowid succeeded in the design and realization of this platform in which all process critical equipment is combined in one compact and robust apparatus, easy to control, and ready to use in environments that meet pharmaceutical standards.

HercuTech 1.0

EmulTech B.V. called the ready to use platform ‘HercuTech’ and it will be part of their development projects for clients. By means of the HercuTech, thorough and fast research and development work can be performed to determine the process variables of the drug delivery formulations.

Flowid B.V. once again showed their capability to realize small and compact ‘skids’ in which large amounts of equipment is efficiently combined. Hereby, the ease of use is drastically being increased while reducing the wear on sensitive and expensive equipment.

Wessel Hengeveld, the Director Technology of Flowid, is pleased with the realization of the skid. “The well thought through design of the skid resulted in a system that fulfills all requirements of EmulTech and their clients. Besides the fact that it works exactly as foreseen, it also looks terrific and it’s easy to use. Flowid really showed their capability to realize small scale skids for laboratorial use.”

Robin de Bruijn, the CTO of EmulTech, adds: “The HercuTech platform really enables us to meet the demands of our clients and fulfill their needs. Now, EmulTech can perform feasibility studies even more flexible and even take the whole platform to the client on a simple and effective manner, ready for them to use it as well and experience the capabilities the ET4ME technology provides.”

EmulTech B.V. develops drug delivery systems using its superior microparticulate technology. This proprietary Emulsion Technology for Micro Encapsulates (ET4ME) is a highly versatile process, providing solutions to many current market demands, including uniformity, and reproducibility issues. The company is able to quickly test various formulations, requiring only small volumes and its parallel scale up strategy allows for swift and reproducible scale up.

Flowid B.V. is an engineering firm specialized in production scale implementation of continuous flow chemistry. Flowid offers solutions by providing a broad pallet of related expert services and specialized equipment. In the field of chemical technology Flowid has been awarded several times for its innovative and groundbreaking work.

Flowid is consortium partner in a grant from the Dutch Polymer Institute for the manufacturing of nanomedicines
2012.04.16 Press release by Flowid

Flowid B.V. is consortium partner in a grant that has been awarded by the Dutch Polymer Institute (DPI) to scale-up and optimize the manufacturing of CriPec® nanomedicines, a technology of Cristal Delivery B.V. The strong consortium is beeing completed with the expertise of PolyVation B.V., BioConnection B.V., and the Department of Pharmaceutics (Utrecht University).

The unique platform technology of transiently stable, polymeric nanoparticles called CriPec® is developed by Cristal Delivery. The nanoparticles have an exclusive position in the nanomedicinal field as they combine the best features of known nanoparticles into one tunable system.

The aim of the current project is to make substantial steps forward in the manufacturing and analysis of various intermediates and final polymeric nanomedicines, in order for the CriPec technology® to be ready for clinical development. For this, Flowid will convert the current method of formation to a scaled up continuous process. Besides Flowid and Cristal Delivery, the consortium is extended with other Dutch partners, experts in the field of polymer synthesis (PolyVation B.V.), filling & finishing (BioConnection B.V.) and characterization of nanomedicines (Utrecht University, Department of Pharmaceutics).

2012 Exhibitions
2012.04.01 Press release by Flowid

In 2012 Flowid will be exhibiting at the occaissions listed below. For more information please click the link or contact us.

18th until the 22nd of June Achema
2nd until the 5th of September ISCRE 22
26th until 27th of September Fourth Symposium on Continuous Flow Reactor Technology for Industrial Applications
7th until 8th of November MIFCAB1 in Jordan

Quantum Dot Continuous Flow Processing Breakthrough Achieved
2011.09.13 Press release by Quantum Materials Corporation

With this advance, researchers and manufacturers have the opportunity to now incorporate Quantum Materials Tetrapod Quantum Dots into new state-of-the-art electronics products that require industrial scale amounts of material.

This new quantum dot production process using a new microreactor and software controlled continuous flow process has been successfully developed and operated for delivery of mass produced quantum dots by Quantum Materials Corporation and the Access2Flow Consortium of The Netherlands. It replaces batch synthesis and has potential for high improvement in both yield and conversion. Tetrapod Quantum Dots are used in a variety of emerging applications including solid state lighting, QLED displays, nanobio applications and are proven to have superior performance characteristics surpassing spherical nanoparticles. This process will also be used for QMC’s subsidiary, Solterra Renewable Technologies' solar cells and solar panels.

The inherent design of the microreactor allows for commercial-scale parallel modules to achieve large production rates at low cost in a regulated, optimized system. This breakthrough production process provides flexibility in the choice of materials used to produce the quantum dots including heavy metal free (Cadmium Free) quantum dots and other biologically inert materials. Quantum dots have been widely recognized for their potential in next generation display technologies, solar cells, LEDs, OLEDs, computer memory, printed electronics and a vast array of security, biomedical and energy storage applications. According to research group BCC Research, the 2010 global market for quantum dots was estimated $67 million in revenues, and is projected to grow quickly over the next 5 years at greater than 50% per year reaching almost $670 million by 2015.

Quantum Materials offers to manufacturers that it is now realistic to test the advantages of quantum dots to establish higher performance benchmarks across a number of industries and product applications. Many discoveries have literally been held back by the difficulty in manufacturing quantum dots, the lack of quality and uniformity of quantum dots, and the corresponding high cost, with the current average cost of quantum dots running being between $2500 and $6000/gram. This technology removes the roadblock from widespread adoption of the quantum dot as a basic building block of technology and services much like the silicon chip that has ubiquitously advanced corporate function and consumer lifestyles worldwide.

”Our goal from the onset has been to achieve a production rate of 100kg per day with a 95% or greater yield,” according to Stephen Squires, Founder and CEO of Quantum Materials Corporation. He added that “with this breakthrough QMC has coupled two disruptive technologies resulting in the potential to now achieve that goal.” According to QMC’s Chief Technical Officer, Dr. Bob Glass “Besides the scalability indicated, in my opinion, the truly remarkable accomplishment in this breakthrough is its adaptability to other inorganic metals and elements, including cadmium-free Quantum Dots.”